Effect of dosage and vaccination route on transmission of a live attenuated Mycoplasma gallisepticum vaccine: a broiler model.

نویسندگان

  • J D Evans
  • S L Branton
  • S A Leigh
چکیده

Mycoplasma gallisepticum (MG) is an economically significant pathogen of poultry species. Among the table egg sector of the poultry industry, live attenuated strains of MG are commonly used to limit production losses associated with MG-induced disease. These vaccines, however, may be problematic to broiler- and turkey-related industries because of associated virulence; therefore, an understanding of the transmissibility of the live MG vaccines is of particular importance. In the present study, a broiler model addresses the effect of vaccine application route and dosage on the transmission of the MG vaccine FVAX-MG to commingled unvaccinated subjects for 7 wk postvaccination. Vaccinations occurred at 2 wk of age via eyedrop or spray application at 1 x (4 x 10(6) colony-forming units [cfu]), 10(-3) x (4 x 10(3) cfu), or 10(-6) x (4 cfu) of the manufacturer's recommended dosage, and subsequent transmission to unvaccinated subjects was measured. The serologic response to MG antigen and the presence of MG DNA indicated FVAX-MG transmission only within the 1 x FVAX-MG eyedrop treatment. Among no other treatment was transmission of FVAX-MG detected. The results of the present study demonstrate that the dosage and vaccination route may have direct implications on subsequent transmission of FVAX-MG.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mycoplasma gallisepticum: Current and Developing Means to Control the Avian Pathogen

Mycoplasma gallisepticum (MG) is a persistent, highly transmissible chicken and turkey pathogen. Infections of the organism can yield significant losses in performance and associated economics to all sectors of the poultry industry. In this paper, potential and realized effects of MG on the poultry industry are discussed along with currently available and developing control methods. Available m...

متن کامل

Identification of Strain-Specific Sequences That Distinguish a Mycoplasma gallisepticum Vaccine Strain from Field Isolates

Despite attempts to control avian mycoplasmosis through management, vaccination, and surveillance, Mycoplasma gallisepticum continues to cause significant morbidity, mortality, and economic losses in poultry production. Live attenuated vaccines are commonly used in the poultry industry to control avian mycoplasmosis; unfortunately, some vaccines may revert to virulence and vaccine strains are g...

متن کامل

SESSION P 142 Mycoplasma gallisepticum isolates from chicken - flocks in Jordan and their relation to live vaccines

S OF PAPERS 235 larly and intranasally with virulent Ark virus on day 30. Necropsy was performed on day 35 and clinical signs, sera, and virus detection were analyzed. Vaccine replication was not detected in a significant number of broilers until day 24 post vaccination and SPF chickens until day 28 post vaccination. Following challenge, 14 of 20 SPF and 9 of 20 broiler chickens tested positive...

متن کامل

Isolation of Ornithobacterium rhinotracheale from the chickens of a broiler farm in Kermanshah province, west of Iran

On June 2005, a respiratory disease was observed in the chickens of a large broiler farm in Kermanshahprovince, west of Iran. Relatively severe respiratory signs started with sneezing at 27 days of age. Thedisease lasted up to the end of fattening period and accompanied by increased mortality (13.6%). At postmortemexamination, tracheitis, airsacculitis and pneumonia were obvious. Serologic exam...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Avian diseases

دوره 53 3  شماره 

صفحات  -

تاریخ انتشار 2009